Abstract Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops).Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.Using unbiased interactomics, biochemical screening, molecular biology, and super-resolution imaging, we
Honey is a sweet and healthy food produced by honeybees (Apis mellifera L.) from flower nectars.Using bidimensional zymography, we have detected the, until now unrevealed, proteolytic activities present in row honey samples.The resulting zymograms were specific for each type of the four unifloral honey under study, and enzymes were identified as se
The objective of the present study was to investigate the associations between major diseases (clinical mastitis, peracute mastitis, metabolic disorders, peripartum disorders) and four parameters related to productivity (305-day milk Satchel yield, number of days open, culling rate, death rate) on a large dairy farm in a temperate zone with approxi